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Saturday, August 7, 2010

Fwd: [MedicalConspiracies] Sci-fi food - Read what products contain Senomyx and avoid - it is not listed on the label except under artificial flavors



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Date: Sat, Aug 7, 2010 at 12:33 PM
Subject: [MedicalConspiracies] Sci-fi food - Read what products contain Senomyx and avoid - it is not listed on the label except under artificial flavors
To: "1 Health_and_Healing@yahoogroup" <Health_and_Healing@yahoogroups.com>, "1 MedicalConspiracies@googlegro" <MedicalConspiracies@googlegroups.com>, "1 Paranormal_Research@yahoogrou" <Paranormal_Research@yahoogroups.com>


SENOMYX, SWEETER THAN SWEET; SALTIER THAN SALT;
MORE SOUR THAN AN ABORTED FETUS

By Robert Cohen
Web Site: <http://www.notmilk.com>http://www.notmilk.com
Posted: 13 March 2009 Sugar, ahhh - - honey honey you are my candy girl and you got me wanting you I just can't believe the loveliness of loving you (I just can't believe its true) I just can believe the wonder of this feeling too (I just can't believe its true) --Wilson Pickett, 1970 (Written by Barry and Andy Kim) We are witnessing the dawning of a sci-fi food revolution. A new technology. A new food group. Amazingly, my research uncovered something nobody has ever revealed before in a column, newspaper article, or magazine expose. The next time you read "artificial flavor" on a food label, you should be aware that a component of that new genetically engineered food additive may be embryonic kidney cells from aborted human fetuses. The new high-tech artificial flavors are not flavors at all. Instead, they contain chemicals which have been engineered to fool human taste buds. Future foods will need no salt, sugar, MSG, or artificial sweeteners. Instead, sensory perceptions will become warped by modern science. Brains will taste things that are not really there. Illusions. Deceptions. Memories of taste which are now artificially induced. You may not understand the abstract of the most recent publication from this new food science, as published in the May 2, 2008 issue of the Journal of Biochemistry. I will translate. The Abstract: @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@

J Biol Chem. 2008 May 2;283(18):11981-94.
Small molecule activator of the human epithelial sodium
channel.Lu M, Echeverri F, Kalabat D, Laita B,
Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto
J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD.
Senomyx, Inc., San Diego, California 92121.

The epithelial sodium channel (ENaC), a
heterotrimeric complex composed of alpha, beta,
and gamma subunits, belongs to the ENaC/degenerin
family of ion channels and forms the principal
route for apical Na(+) entry in many reabsorbing epithelia.

Although high affinity ENaC blockers, including
amiloride and derivatives, have been described,
potent and specific small molecule ENaC
activators have not been reported. Here we
describe compound S3969 that fully and reversibly
activates human ENaC (hENaC) in an
amiloride-sensitive and dose-dependent manner in
heterologous cells. Mechanistically, S3969
increases hENaC open probability through
interactions requiring the extracellular domain
of the beta subunit. hENaC activation by S3969
did not require cleavage by the furin protease,
indicating that nonproteolyzed channels can be
opened. Function of alphabetaG37Sgamma hENaC, a
channel defective in gating that leads to the
salt-wasting disease pseudohypoaldosteronism type
I, was rescued by S3969. Small molecule
activation of hENaC may find application in
alleviating human disease, including
pseudohypoaldosteronism type I, hypotension, and
neonatal respiratory distress syndrome, when
improved Na(+) flux across epithelial membranes is clinically desirable.

@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
@@@@@@@@

OK, so what does it all mean? Another question:

What's $6 today and $100 in the Near Future? SNMX trades on NASDAQ

<http://www.senomyx.com>http://www.senomyx.combioportfolio.com) will provide more info than
you need to know. See: United States Patent #5,993,778.

How far into the future will these new biotech
wonders appear in our food supply? The future is
now. The next time you read "artificial flavor"
on a food label, pause to consider what you've
read here today. Content labels should read:
Embryonic kidney cells from aborted human fetuses.

Senomyx is presently developing new products with
many of the world's largest food manufacturers
including Campbell's and Coca Cola. In fact, if
you eat Nestle's foods, your taste buds are being
artificially stimulated by biotech products
developed by Senomyx. You may now know what you
are eating, but I take this opportunity to
paraphrase 17th century author Miguel Cervantes, who wrote in Don Quixote:

"The proof is in the pudding."

Robert Cohen
<http://www.notmilk.com>http://www.notmilk.com<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=1>Food
Industry News

Categories:
<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=6>Corpora
From the Senomyx website: Translation: Senomyx is re-inventing food and flavor by genetically engineering taste bud receptor cell triggers. Foods of the future will contain "flavor enhancers" which fool human taste buds into perceiving the sensations of sweetness, sourness, saltiness, and bitterness. Remember the artificial sweetener controversies? Chemical sugar-replicating compounds are listed on food labels. The new chemicals made by biotech companies will require no such labels. Although they are not actual flavors, they will be called "artificial flavors." How did Senomyx accomplish the task? A (multi-hour) review of their patents reveals that it all began with the cloning of human embryonic kidney cells. Step two was a recombinant process involving the combination of genetic material from embryonic kidney cells and human adeno-virus. If I had the ability to recall ten thousand abbreviations for the amino acid sequence, plus hundreds of complex combinations of ACTG (adeneine, cytosine, thymine, guanine) I'd describe the structure to you. For those curious scientists, do a google search with the keywords 'Senomyx and patents' and the third link ( Friday, 6 August 2010, 9:41 :. te
Results |
<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=16087>Foo
d
Ingredients News




Senomyx Q2 Revenues Up 91%; Outlook Encouraging

Source: Senomyx, Inc
05/08/2010
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August 5 - Senomyx, Inc., a company focused on
using proprietary taste receptor-based
technologies to discover novel flavor ingredients
for the food, beverage, and ingredient supply
industries, today provided a corporate update and
reported financial results for the second quarter ended June 30, 2010.

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Revenues were $5.7 million for the second quarter
of 2010, compared to $3.0 million for the second
quarter of 2009, an increase of 91%. Revenues
were $13.4 million for the six months ended June
30, 2010, compared to $6.5 million for the six
months ended June 30, 2009, an increase of 107%.
As of June 30, 2010, the Company had cash, cash
equivalents, and short term investments of approximately $55.4 million.

The second quarter of 2010 has been very active
for Senomyx, stated Kent Snyder, Chief Executive
Officer of the Company. During the quarter we
were informed that the European Food Safety
Authority (EFSA) has provided a favorable
opinion for Senomyx s Savory Flavor Ingredients,
S336 and S807, which means that no further
evaluation is required. The successful conclusion
of the evaluation is a key step toward receiving
an approval to use these ingredients in the European Union.

Senomyx s Savory Flavor Ingredients are intended
to reduce or replace added monosodium glutamate
(MSG) in foods and beverages. Final regulatory
approval and commercialization in the EU is
contingent upon the ingredients being included in
the EFSA Union List, which EFSA has targeted for
publication by the end of 2010.

Nestlé, the world s largest food and beverage
company, is currently conducting marketing
activities in the Pacific Rim, Latin America, and
Africa with both new and reformulated established
products that incorporate Senomyx s Savory Flavor
Ingredients. Approval in Europe could create a
new market opportunity for Nestlé, Snyder noted.

In addition, Ajinomoto, a leading global
manufacturer of food and culinary products, is
introducing products that contain a Senomyx
flavor ingredient in Asia and another key
region, Snyder stated. Ajinomoto has increased
the number of products launched and has also
selected several new Senomyx flavor ingredients
for potential marketing. Selection of the new
ingredients, which are all currently being
evaluated by Ajinomoto, triggered a $500,000 milestone payment to Senomyx.

Another Senomyx partner, Firmenich, is
continuing commercial activities for Senomyx s
extremely effective enhancer of the
high-intensity sweetener sucralose (S2383),
Snyder said. Firmenich SA, a global leader in
providing ingredients and flavor systems to major
consumer companies, has exclusive worldwide
rights to market the sucralose enhancer as either
a stand-alone ingredient or as part of a flavor
system in all food and beverage product categories.

Senomyx s recent scientific achievements include
important progress in our Bitter Blocker Program
during the past quarter, Snyder noted.
Development activities, including primary safety
studies, have now been completed for our S6821
Bitter Blocker, allowing Senomyx to submit
regulatory filings for S6821 in the second half
of the year. S6821 is effective in reducing the
bitterness of a variety of product prototypes. We
are encouraged by the accelerated pace of our
development activities and the potential
long-term value of our Bitter Blocker Program.

We are also enthusiastic about the success
Senomyx has had with our Sweet Enhancer program,
Snyder commented. As announced on June 24, our
advances in this program have led to Senomyx and
PepsiCo, the world s second-largest food and
beverage company, signing a letter agreement and
entering into an exclusive 60-day negotiation
period regarding the completion of a definitive
agreement for a new collaboration related to
Senomyx s sweet taste technology.

Senomyx s letter agreement with PepsiCo includes
key commercial and financial terms for a
potential multi-year collaborative research
program focused on the discovery, development,
and commercialization of new artificial sweet
enhancers, natural sweet enhancers, and natural
high potency sweeteners for the non-alcoholic
beverage category. Under the letter agreement,
Senomyx has received a payment of $7.5 million
from PepsiCo. The payment, which is
non-refundable except under limited
circumstances, will be applied as partial payment
towards an upfront license fee if Senomyx and
PepsiCo enter into a final definitive agreement.

PepsiCo is an innovative company that shares our
commitment to providing healthier, great-tasting
products to consumers. We believe that our
potential new collaboration would include a
commercialization timeframe and other terms that
are beneficial for both companies, Snyder stated.

In addition to other accomplishments, the Company
increased its intellectual property portfolio
during the past quarter. As of June 30, 2010,
Senomyx is the owner or exclusive licensee of 207
issued patents and 362 pending patent
applications related to proprietary taste
receptor technologies in the U.S., Europe, and
elsewhere. Technologies covered in the Company s
patents include taste receptor sequences and
functions, screening assays, new flavor ingredients, and product applications.

Senomyx achieved its recent scientific advances
under the leadership of Donald S. Karanewsky,
Ph.D., who has served as Senior Vice President,
Discovery since joining Senomyx in June 2007. In
recognition of his valuable contributions to the
Company, Dr. Karanewsky was appointed to the
position of Senior Vice President and Chief
Scientific Officer during the past quarter. Dr.
Karanewsky received his Ph.D. and Master s
degrees in Chemistry from Harvard University and
was granted a B.S. in Chemistry, Magna Cum Laude,
from Stevens Institute of Technology in New Jersey.

Senomyx management will discuss the Company s
recent events during a conference call at 11:00
a.m. Eastern Time (8:00 a.m. Pacific Time) today.
Details regarding access to the call and a
subsequent archived recording are provided below.

Discovery & Development Program Updates:

Sweet Enhancer Program: The primary goal for this
program is to identify flavor ingredients that
allow a significant reduction of sweeteners in
food and beverage products while maintaining the
desired sweet taste. Senomyx has received a GRAS
(Generally Recognized As Safe) regulatory
designation for S6973, the Company s sucrose
enhancer that enables up to 50% reduction of
sugar in certain foods and beverages while
maintaining the sweet taste of natural sugar. The
GRAS designation allows it to be used in the U.S.
and in numerous other countries for most food
products and selected beverages such as flavored
milk, as well as ready-to-drink and instant
coffee and tea. The sucrose enhancer is currently
being evaluated by potential collaborators
interested in using it for these beverage
categories. Firmenich has exclusive worldwide
rights to commercialize this sucrose enhancer for
virtually all food categories, and co-exclusive
rights for the powdered beverage category.
Firmenich has initiated pre-commercialization
activities with major clients in anticipation of
conducting its first product launches during 2011.

Additional advances with the Sweet Enhancer
Program include the identification of a new
family of sucrose enhancers with distinct
physical properties that may be advantageous for
a broader range of beverages and other product
applications. A recently discovered sucrose
enhancer from this family enables up to 50%
reduction of sugar in preliminary taste tests.

During the first quarter of 2010, the Company
identified the first Senomyx flavor ingredients
that demonstrate a statistically significant
amplification of the sweet taste of fructose, a
key component of high fructose corn syrup. High
fructose corn syrup is the primary sweetener used
in carbonated and certain other beverages,
especially in North America. A number of new
samples have been active in the fructose enhancer
screening assay. These are being optimized to
increase their potency and improve their physical
properties, followed by evaluation in taste tests.

Bitter Blocker Program: The primary goals of this
program are to reduce or block bitter taste and
to improve the overall taste characteristics of
foods, beverages, and ingredients. Taste tests
have demonstrated that S6821 and S0812, alone or
in combination, can provide statistically
significant reductions in the bitterness of a
variety of product prototypes and food
ingredients including tea, cocoa, menthol,
various proteins, and the sweeteners
Rebaudioside-A (a derivative of the stevia
plant), Acesulfame potassium (Ace-K), and
saccharine. Senomyx expects to submit regulatory
applications for S6821 during the second half of
this year. In addition, the Company believes
development activities with S0812 will conclude
by year-end and regulatory filings are planned for 2011.

Salt Enhancer Program: The goal of the Salt
Enhancer Program is to identify flavor
ingredients that allow a significant reduction of
sodium in foods and beverages yet maintain the
salty taste desirable to consumers. Senomyx
discovered SNMX-29, a protein with
characteristics that indicate it could be
involved in human salt taste perception, and
identified samples that are active in screening
assays based on this protein. These active
samples have not provided significant enhancement
of saltiness in taste tests, which leads the
Company to believe that SNMX-29 is not the
primary receptor responsible for human salt
taste. The Company is exploring the role of other
proteins that may be integral to the sensation of
salty taste. This high-priority effort involves
chemistry and biology approaches, including
assessing components of Senomyx s proprietary
database of proteins found in taste buds. Senomyx
believes that discovery of the protein or
proteins that function as the salt taste receptor
could lead to identifying a salt taste enhancer.

Cooling Flavor Program: The goal of the Cooling
Flavor Program is to identify novel cooling
flavors that do not have the limitations of
currently available agents. Senomyx has
discovered new cooling flavors that demonstrated
a taste proof-of-concept and displayed cooling
properties that exceed those of commonly used
agents. Senomyx and its partner for this program,
Firmenich, have prioritized sample classes that
are the focus of further optimization.

Financial Review:

Revenues were $5.7 million for the second quarter
of 2010, compared to $3.0 million for the second
quarter of 2009, an increase of 91%. Revenues
were $13.4 million for the six months ended June
30, 2010, compared to $6.5 million for the six
months ended June 30, 2009, an increase of 107%.
The increases in revenues for the second quarter
and the year-to-date were primarily due to the
recognition of license fee and R&D funding
revenue related to the Company s August 2009
Sweet Enhancer collaboration with Firmenich.
License fee and R&D funding related to the
collaboration contributed $3.3 million and $6.2
million for the three and six month periods
ending June 30, 2010. Also contributing to the
increase year-to-date was a total of $3.0 million
in non-recurring milestone payments and cost
reimbursements from collaborators.

Research and development expenses, including
stock-based compensation expense, were $7.1
million for the second quarter of 2010, compared
to $7.8 million for the second quarter of 2009, a
decrease of 10%. Research and development
expenses, including stock-based compensation
expense, were $13.5 million for the six months
ended June 30, 2010, compared to $15.4 million
for the six months ended June 30, 2009, a
decrease of 13%. These decreases were primarily
due to reduced expenditures for compound
acquisition and related high-throughput screening
activities and reduced personnel-related expenses.

General and administrative expenses, including
stock-based compensation expense, were $3.3
million for the second quarter of 2010, compared
to $3.2 million for the second quarter of 2009,
an increase of 3%. General and administrative
expenses, including stock-based compensation
expense, were $6.4 million for the six months
ended June 30, 2010, compared to $6.5 million for
the six months ended June 30, 2009, a decrease of 1%.

The net loss for the second quarter of 2010 was
$0.12 per share, compared to a net loss of $0.26
per share for the second quarter of 2009. The net
loss for the six months ended June 30, 2010 was
$0.18 per share, compared to $0.50 per share for
the six months ended June 30, 2009.

2010 Outlook:

Due to the receipt of $7.5 million from PepsiCo
related to the June letter agreement, we are
revising our cash utilization guidance for 2010
from a range of $14 million to $16 million to a
range of $6 million to $8 million. At this time,
we are not revising our other financial guidance
metrics; however, we will update our financial
guidance as necessary if we enter into a
definitive agreement with PepsiCo, stated Tony
Rogers, Vice President and Chief Financial Officer.

For the full year 2010, Senomyx now expects:
Total revenues of $20 million to $24 million
Total expenses of $42 million to $44 million, of
which $5 million to $6 million is non-cash,
stock-based compensation expense Net loss of $18
million to $21 million Basic and diluted net loss
of $0.48 to $0.56 per share Net cash used in
operating activities between $6 million and $8 million


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